Blogs Written by Dr. Oenbrink

Analysis of the Babesia microti proteome in infected red blood cells by a combination of nanotechnology and mass spectrometry

A proteome is a set of all expressed proteins in a cell, tissue, or organism, and a systematic analysis of proteins within a defined system for their identity, quantity, and function is called proteomics. Nanotechnology promises other ways to diagnose Babesia & other illnesses. Babesia is a tick borne illness that presents with irregular fevers, chills, headaches, general lethargy, pain, and malaise. It can be lethal in immunocompromised folks. Very hard to diagnose with current lab techniques, help on help on the way?

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Two-Tier Testing for Lyme Disease: How it Evolved

Historically, a less expensive very sensitive screening test is done for certain illnesses. Sensitive means low risk of false negative (you have the illness but test says you don’t) but high risk of false positives (you don’t have the disease, but the test says you do). Next a more Specific test is done that often is more expensive but more likely to not have false negatives; if this test says you are afflicted, you probably are. It’s important to understand this; Western Blot is the specific test.

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Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases

Disulfiram, otherwise known as Antabuse, is used to treat alcoholics, it inhibits the oxidation of the aldehydes produced by metabolism of ethanol causing severe side effects and misery for anybody consuming alcohol. I wonder what the circumstances were for some creative clinician to try to use it on Babesia patients…

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Ciprofloxacin dramatically affects the mitochondrial genome

Theory has it that the mitochondria–power plants of the cell may have been symbiotically acquired during the development of eukaryotes–complex cells, this would fit in the mechanism of action of the Flouroquinolone class of antibiotics that disrupt the topoisomerase enzymes responsible for maintenance of the DNA genome of microbes–that’s how it works. That it also affects our mitochondria is interesting–why some folks and not others–more research needed!

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When antibiotics turn toxic

So many practitioners turn to these drugs without a second thought of the potential harm they can cause. Additionally, they’re class of drug that is effective against difficult infections and shouldn’t be used for common illnesses to avoid resistance patterns—yet they are overused anyway.

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Bartonella henselae- and quintana-associated uveitis: a case series and approach of a potentially severe disease with a broad spectrum of ocular manifestations

Uveitis is inflammation of the anterior chamber of the eyeball. It can lead to blindness if not recognized and treated appropriately–often with steroids which suppress inflammation. I would not think of Cat-Scratch Fever as a cause, further, steroids could make it easier to spread by suppressing protective inflammation to much. Antibiotics would probably be a better choice of initial treatment, with or without antibiotics. History of Present Illness is so important in medicine!

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Chronic Inflammatory Response Syndrome in Children

CIRS causes as many or” more problems in kids as adults. Not as many criteria are needed to make the diagnosis, the most common presentation? Headache, bellyache, fatigue. Also look for bed wetting/delay in toilet training, “growing pains” that last for months, irritability and a variety of other problems. Dr’s Gupta & McMahon do a great job of reviewing the peculiarities of this illness in kids. Worth the listen (or read)

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Requirements for use of Vasoactive Intestinal Peptide (VIP)

VIP “cleans out the dust & cobwebs and puts on a fresh coat of paint”. It truly is a miracle drug that can actually cure pulmonary hypertension–which typically has a life expectancy of about 5 years (I was diagnosed in 2014, cured in 2019). It also helps with pain, inflammation, mitochondrial function. It’s naturally produced in the body, only available from compounding pharmacies and can only be used when pre-requisites are met or it won’t work properly.

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Pathways of inflammation and cell death in the lung: modulation by vasoactive intestinal peptide

Chronic Inflammatory Response Syndrome causes lethal pulmonary hypertension–which can fully resolve with VIP treatment–yet severe shortness of breath & exercise tolerance can persist due to mitochondrial dysfunction and a diminished VO2 Max. Mitochondrial support supplements are needed but VIP should also be continued.

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To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia

Piroplasmids divide by binary fission and as sporozoan parasites they possess sexual and asexual forms. The haploid state in the human host should make QPCR nucleic acid probing possible, but with a rapidly mutating/evolving species that may not be enough. We need to identify preserved antigenic structures on it’s cell membrane and other means for intracellular antibiotics to do their work…

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Where Lyme Disease Came From and Why It Eludes Treatment

Phenomonal investigative reporting! So Plum Island CT & the US Dept. of Defense produced Lyme disease by making Borrelia much more toxic & downright deadly. Who released it and why? Agenda 21? Does the DOD have better ways to treat it than we currently have? Bioweapons, weaponized ticks, “national autoimmunity” are/were we being attacked by our own government? The Tuskeegee Syphilis Study also used spirochetes.

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Values & Performance of diagnostic tests for different species of spirochetes

Spirochetes as a phylum are difficult to study. Polymerase Chain Reaction immunological studies are the best lab tests we have to date. Syphillis, Lyme, Relapsing Fever, & Leptospirosis are the 4 major illnesses caused by these organisms. Unfortunately lab tests are plagued by false negative & positive tests; a high index of suspicion is necessary and may require repeated testing.

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Physicians Get Addicted Too

For years physicians were taught (falsely, due to Purdue’s deception) that opioids were safe for long term use. Now, guys like Lou Ortenzio, a great physician by the report of this article will NEVER practice again. We NEED to have a SANE system in place to rehab physicians and get them back into practice! Physician’s Health Programs can be helpful, but are often corrupt as are State Medical Boards! THEY need the regulation!

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Denver first in U.S. to decriminalize psychedelic mushrooms

These localities start with decriminalization, then “medically necessary” legalization, next comes “recreationally legal” with great tax income–only to be followed by increased public health costs for indigent care as users suffer “unexpected” problems and other, often indigent folks migrate to those areas…

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Blogs Written by Dr. Oenbrink

image002 Dr. Raymond Joseph Oenbrink

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