Walter K. Kraft, M.D., Susan C. Adeniyi-Jones, M.D., Inna Chervoneva, Ph.D., Jay S. Greenspan, M.D., Diane Abatemarco, Ph.D., Karol Kaltenbach, Ph.D., and Michelle E. Ehrlich, M.D.

N Engl J Med 2017; 376:2341-2348June 15, 2017DOI: 10.1056/NEJMoa1614835


Current pharmacologic treatment of the neonatal abstinence syndrome with morphine is associated with a lengthy duration of therapy and hospitalization. Buprenorphine may be more effective than morphine for this indication.


In this single-site, double-blind, double-dummy clinical trial, we randomly assigned 63 term infants (≥37 weeks of gestation) who had been exposed to opioids in utero and who had signs of the neonatal abstinence syndrome to receive either sublingual buprenorphine or oral morphine. Infants with symptoms that were not controlled with the maximum dose of opioid were treated with adjunctive phenobarbital. The primary end point was the duration of treatment for symptoms of neonatal opioid withdrawal. Secondary clinical end points were the length of hospital stay, the percentage of infants who required supplemental treatment with phenobarbital, and safety.


The median duration of treatment was significantly shorter with buprenorphine than with morphine (15 days vs. 28 days), as was the median length of hospital stay (21 days vs. 33 days) (P<0.001 for both comparisons). Adjunctive phenobarbital was administered in 5 of 33 infants (15%) in the buprenorphine group and in 7 of 30 infants (23%) in the morphine group (P=0.36). Rates of adverse events were similar in the two groups.


Among infants with the neonatal abstinence syndrome, treatment with sublingual buprenorphine resulted in a shorter duration of treatment and shorter length of hospital stay than treatment with oral morphine, with similar rates of adverse events. (Funded by the National Institute on Drug Abuse; BBORN number, NCT01452789.)


Buprenorphine is an AWESOME medication.  Since coming onto the market it’s been 1st choice for treating pregnant women.  It’s safer for the baby!  This is a great review that emphasizes the use of Buprenorphine (BUP) in the baby after birth as well as before birth and shows that we can get these babies off of opiates much faster than by using morphine or other straight opiate agonists.

Dr. Raymond Oenbrink