Gary A. Enos, Editor

At doses that by themselves would produce no effect, a combination of oxazepam and metyrapone (a cortisol synthesis inhibitor) was found in a study published in 2008 to reduce cocaine self-administration in rats. That research attracted the interest of investors and the establishment of Boston-based pharmaceutical company Embera NeuroTherapeutics, Inc.

Currently, we know of a few medications that can be used off-label to help with cocaine abuse;

  • Vigabatrin
  • Gabapentin
  • Baclofen
  • N-acetylcysteine
  • Nocaine
  • Disulfiram
  • Modafinil

It will be nice to have other options, more effective options, this is an interesting study

Dr. Raymond Oenbrink
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