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Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists
https://advances.sciencemag.org/content/5/11/eaax9115 Comment; What amazing research! To discern at the Ångstrom level; 10X10-10 Meter level. Now we can map the delta δ opioid receptor active in pain relief, drug reward, inhibitory controls and learning processes....
Post traumatic stress, alcohol use, and alcohol use motives among firefighters: The role of distress tolerance
https://www.sciencedirect.com/science/article/abs/pii/S0165178119315860?via%3Dihub Comment; PTSD & distress tolerance as well as coping mechanisms all go hand in hand, let's define more about these relationships in this vulnerable population. Author links open...
New tools needed in the fight against substance use disorder
https://www.bostonglobe.com/2019/12/05/opinion/new-tools-needed-fight-against-substance-use-disorder/ Comment; The Medication Access and Training Expansion (MATE) act is yet another battle on the war on drugs. Will it work? Time will tell. The better approach will be...
Drugs that quell brain inflammation reverse dementia
https://news.berkeley.edu/2019/12/04/drugs-that-quell-brain-inflammation-reverse-dementia/ Comment; This information furthers the seminal work of Dale Bredesen MD & Ritchie Shoemaker MD with practical applications to the epidemic of dementia in the US. Many...
The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?
https://www.ncbi.nlm.nih.gov/pubmed/27346602 Comment; Host energy metabolism and immune functions critically depend on butyrate as a potent regulator, highlighting butyrate as a key mediator of host-microbe crosstalk, butyrate and other volatile SCFAs produced by...
Stable gastric pentadecapeptide BPC 157-NO-system relation.
https://www.ncbi.nlm.nih.gov/pubmed/23755725 Comment; P entadecapeptide BPC 157 Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Aralica...
Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/#r22 Comment; Pentadecapeptide BPC 157 appears to be a reasonable replacement for Vasoactive Intestinal Peptide (VIP) in the treatment of chronic inflammatory disorders including central neurologic issues. Predrag...
Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories
https://www.nature.com/articles/s41467-019-13162-w Comment; Maladaptive Reward Memory + Ketamine--> effectively reduced the reinforcing effects of alcohol and long-term drinking levels. This could have profound implications for treatment of long-term alcoholism! Ravi...
Life Expectancy and Mortality Rates in the United States, 1959-2017
https://jamanetwork.com/journals/jama/article-abstract/2756187 Comment; "By 2014, midlife mortality was increasing across all racial groups, caused by drug overdoses, alcohol abuse, suicides, and a diverse list of organ system diseases." Add to this the decreased...
A cortical-brainstem circuit predicts and governs compulsive alcohol drinking
https://science.sciencemag.org/content/366/6468/1008 Comment; Medial frontal to brainstem bidirectional circuit that influences compulsive alcohol consumption in rats--probably can be scaled up to humans--more study needed to verify. Cody A....
Short- and Long-Term Effects of Cannabis on Headache and Migraine
https://www.jpain.org/article/S1526-5900(19)30848-X/fulltext Comment; Cannabis concentrate works better than flower, men respond better than women, migraine & HA are both helped, medication tolerance does develop but overuse was not appreciated.
Effect of Intranasal vs Intramuscular Naloxone on Opioid Overdose A Randomized Clinical Trial
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2755306 Comment; IM is better than IN as a route for emergency delivery of Naloxone to reverse opioid overdose. Paul Dietze, PhD1,2; Marianne Jauncey, MPH...
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