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The role of gut microbiome and associated metabolome in the regulation of neuroinflammation in multiple sclerosis and its implications in attenuating chronic inflammation in other inflammatory and autoimmune disorders.
https://www.ncbi.nlm.nih.gov/pubmed/29392733 Comment; We're learning so much about the interactions between the gut, microbiome & brain, peripheral T-Cells & chemokines/cytokines and other small regulatory molecules that have to be elucidated clearly have a...
Interaction between blood-brain barrier and glymphatic system in solute clearance.
https://www.ncbi.nlm.nih.gov/pubmed/29608988 Comment; A greater appreciate of the interplay between the BBB & Glymphatic system is occuring. It'll be interesting to further define activity of the immune system in this process as well. We've already established...
Loneliness in healthy young adults predicts inflammatory responsiveness to a mild immune challenge in vivo
https://www.sciencedirect.com/science/article/pii/S0889159119303174?dgcid=raven_sd_aip_email Comment; Interesting study showing something we've suspected for a long time. Loneliness is a stressor, folks under stress don't have the immune system strength that healthy...
Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy
https://www.tandfonline.com/doi/abs/10.4161/auto.8.1.18313 Comment; Autophagy is the process by which abnormal products of metabolism are "eaten up" and removed before they can cause (more) damage. It's an essential part of normal homeostasis. Isorhynchophylline...
Evaluation of a novel multiplex high-definition PCR (HDPCR) assay for the detection of tickborne pathogens in whole blood specimens
https://jcm.asm.org/content/early/2019/08/29/JCM.00513-19 Comment; Sensitivity at 10*3 to 10*5 copies/PCR reaction is pretty good sensitivity. A potential problem is the increased rate of false positive results observed among simulated specimens that contained...
Rapid Lyme disease test may be available in late 2020
http://news.cornell.edu/stories/2019/09/rapid-lyme-disease-test-may-be-available-late-2020 Comment; An aptamer-DNA strand that can bind to the Osp-A Borrelia protein would be a game changer if it works as advertised. Being able to determine presence of the disease...
Watch webcast of next TBD Working Group meeting Sept. 12
https://www.lymedisease.org/tbdwg-sept-12/ Comment; Transparency in action, the Federal Tick-Borne Disease Working Group will not only be available to be viewed live, but questions can be submitted in advance and live during the hearing which will involve reports from...
Healing the Blood-Brain Barrier
https://appwell.net/wp-content/uploads/2019/09/BBBHealing.pdf Comment; Suzanne Gazda, MD is an integrative neurologist who has put together a great list of ways to heal the blood brain barrier which protects the brain from a variety of toxic sources of damage. An...
America’s War on Drugs Has Treated People Unequally Since Its Beginning
https://time.com/5638316/war-on-drugs-opium-history/ Comment; A sad commentary on the state of drug enforcement in the US--a state that persists to some degree or other to this day.
What America’s Users Spend on Illegal Drugs, 2006–2016
https://www.rand.org/pubs/research_reports/RR3140.html Comment; People who use drugs in the United States spent on the order of $150 billion on cocaine, heroin, marijuana, and methamphetamine in 2016! That's a LOT of "border walls" to slow the influx of illicit...
Tetrahydrocannabinol Detection Using Semiconductor-Enriched Single-Walled Carbon Nanotube Chemiresistors
https://pubs.acs.org/doi/10.1021/acssensors.9b00762 Comment; Artificial Intelligence meets nano-manufacturing to create something we'd only been able to dream of before, an accurate, hand-held "breathalyzer" that can detect THC levels. Sean I. HwangNicholas G....
Comparison of Trends in Self-reported Cigarette Consumption and Sales in England, 2011 to 2018
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2749052 Comment; Good news for Britain in terms of a billion fewer cigarettes smoked each year, but what about vaping? I still think vaping is safer than smoking (but not safe!) and is a good "bridge" to...
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