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Oxytocin…It’s Not Just About Sex!
https://www.jillcarnahan.com/2016/03/26/oxytocin-not-just-sex/ Comment; Dr. Jill is as personable as she is brilliant. There's another use for Oxytocin not covered in her great article--it's a safe way to treat excessive urination/poor urine concentration (wasting...
Appeals court’s smart move paves the way for opioid addiction treatment in prisons and jails
https://www.statnews.com/2019/06/10/opioid-addiction-treatment-correctional-facilities/ Comment; Many will be surprised to learn that the Americans with Disabilities Act (ADA) covers addiction as a disability--WHEN the addicted is NOT USING (abstinent). While using,...
Enzyme morphinan N-demethylase for more sustainable opiate processing
https://www.nature.com/articles/s41893-019-0302-6 Comment; Wow!, this is the week's best article. Naloxone/Naltrexone are way to expensive, now that a more efficient way to produce such compounds is being identified, will it upscale (appears so!) and more importantly,...
Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1480-x Comment; ZH853 seems to be a superior answer for analgesia at this point, however no mention is made of it's effect on the µ-Opioid receptor agonists which promote euphoria and thus...
Safety and Efficacy of Lofexidine for Medically Managed Opioid Withdrawal A Randomized Controlled Clinical Trial
https://journals.lww.com/journaladdictionmedicine/Fulltext/2019/06000/Safety_and_Efficacy_of_Lofexidine_for_Medically.2.aspx Comment;The cost for Lucemyra oral tablet 0.18 mg is around $786 for a supply of 36 tablets, depending on the pharmacy you visit. The lowest...
Access to Office-Based Buprenorphine Treatment in Areas With High Rates of Opioid-Related Mortality: An Audit Study
https://annals.org/aim/article-abstract/2735182/access-office-based-buprenorphine-treatment-areas-high-rates-opioid-related Comment; Glad that they are able to get care, sad that they need to wait and still have apparent discrimination based on payer source. However,...
Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1898878 Comment; "States with medical cannabis laws had a 24.8% lower mean annual opioid overdose mortality rate". I initially was guilty of withholding Medication-Assisted Treatment to patients using...
‘Become My Mom Again’: What It’s Like to Grow Up Amid the Opioid Crisis
https://www.nytimes.com/2019/05/31/us/opioid-children-addiction.html?action=click&module=Top%20Stories&pgtype=Homepage Comment; Addiction is evil. I truly believe in the spiritual component of addiction, considering it to be a form of satanic attack--destroying lives,...
Kratom-Related Deaths
https://jamanetwork.com/journals/jama/fullarticle/2734336 Comment; Stimulant effect at low doses, opioid effect at high doses. Stimulants are generally the most addicting substances, take a bit more, opioid effect & respiratory depression--to say nothing of...
Chronic use of tramadol after acute pain episode: cohort study
https://www.bmj.com/content/365/bmj.l1849.abstract Comment; I've always thought of Tramadol/Ultram as being the safest, it was originally marketted as non-abusable
The devastating biological consequences of homelessness
https://www.nature.com/articles/d41586-019-01573-0 Comment; Homelessness is a scourge in our society, some folks choose it--usually mentally ill, substance abusers and the like. Others just need a hand up (not out). There are no easy answers, but we need to plan for...
Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832009/ Comment; What a great idea to investigate Oxytocin and amygdala/limbic/emotional system hyper-reactivity; Oxytocin has a great calming effect! This would be beneficial to many of our complex chronic illness...
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