GLA RESPONSE TO PROPOSED IDSA/AAN/ACR 2019 DRAFT LYME DISEASE GUIDELINES

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI, Lyme Disease & Atypical Infections, Neurodegeneration & Brain Health

GLA Response to Proposed IDSA/AAN/ACR 2019 Draft Lyme Disease Guidelines Comment; The Global Lyme Aliance really “knocks it out of the park” with a huge homerun. Very thoughtful, detailed analysis that can cause one to question the IDSA recommendations for...

Could Eating Fish Increase Your Risk of Heart Disease?

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI, Neurodegeneration & Brain Health

Could Eating Fish Increase Your Risk of Heart Disease? Comment; Dr. Jill does her usual stellar job of addressing a complex issue. Trimethylamine N-oxide (TMAO) seems to be an interesting concept with conflicting theories–perhaps just not yet ready for prime...

Melatonin: Clinical Perspectives in Neurodegeneration.

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI, Neurodegeneration & Brain Health

https://www.ncbi.nlm.nih.gov/pubmed/31379746 Comment; Chronobiotic & Cytoprotective (at higher doses), aids in the glymphatic system of the brain–a natural product that we make (but declines with age) can be supplemented easily with a great safety profile,...

NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI, Neurodegeneration & Brain Health

https://drive.google.com/file/d/1OLCvPKU-88Tis6H_cixq_u7V5mDd1Wog/view?usp=sharing Comment; Reduced cerebral NAD+/NADH ratio means impaired energy metabolism in the cell. Supplementation with Nicotinamide Riboside lessened the damage, the pTau pathology and reversed...

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer’s disease and Parkinson’s disease

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI, Neurodegeneration & Brain Health

https://drive.google.com/file/d/1OKyC7Y4tEySVSPBp7vTAQJDF0fCIGy5-/view?usp=sharing Comment; Great summary/comparison/contrast of Alzheimer’s & Parkinson’s–as well as summary of the common disease processes among neurodegenerative illnesses....

Neuronal loss or dysfunction in patients with early Lyme neuroborreliosis: a proton magnetic resonance spectroscopy study of the brain

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI, Lyme Disease & Atypical Infections

https://drive.google.com/file/d/1OJfkkhTxBnVpFlTlJp_n3gfl49xtVBDk/view?usp=sharing Comment; Lyme disease literally causes loss of brain tissue in the frontal area of the cerebral cortex–the part that separates man from animals! Abstract Background We...

Oligodendroglia are protected from antibody-mediated complement injury by normal immunoglobulins

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://drive.google.com/file/d/1O0Zsf_zalnHQGDtQkexgV13VifDBCNVD/view?usp=sharing Comment; Complement is known to be active in chronic inflammatory response syndrome (CIRS). Antibody-dependent complement damage was inhibited in a dose-dependent manner by IV Ig. So...

Oligodendroglia are protected from antibody-mediated complement injury by normal immunoglobulins ‘‘IV Ig’’

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://drive.google.com/file/d/1O0Zsf_zalnHQGDtQkexgV13VifDBCNVD/view?usp=sharing Comment; Many mechanisms of action of IV Immunoglobulins including penetration within the cell membrane and even the nucleus of diseased cells, regulation of the immune system in the...

Fas–Fas Ligand: Checkpoint of T Cell Functions in Multiple Sclerosis

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://drive.google.com/file/d/1OBEdBtnajvuB44DdTe3bB2KoVhVe68tE/view?usp=sharing Comment; Fas-FasL regulate the CD4 ‘helper’ and CD8 ‘cytotoxic/killer’ cells by inducing apoptosis–cell death. MS happens when this regulation goes...

Immunological evidence and regulatory potential for cell-penetrating antibodies in intravenous immunoglobulin

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://drive.google.com/file/d/1OCGMkr5OxSEvsM5HOBbLZvLvEMLL2h2n/view?usp=sharing Comment; Not only does IgG penetrate into cells, but in healthy cells, it gets into the cytoplasm, in diseased cells, to the nucleus; where the action is in terms of cellular control....

Maybe It’s Lyme What happens when illness becomes an identity?

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI, Lyme Disease & Atypical Infections

https://www.thecut.com/2019/07/what-happens-when-lyme-disease-becomes-an-identity.html Comment; It is a problem, yet an understandable one. Few physicians are truly Lyme-literate, the infection is hard to diagnose with contradictory criteria from major organizations,...

The Emerging Science of BMAA; DO CYANOBACTERIA CONTRIBUTE TO NEURODEGENERATIVE DISEASE?

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://mail.google.com/mail/u/2/#inbox/FMfcgxwDqfLDcrXHnCWkRNzjHdDPgFTh?projector=1&messagePartId=0.1 Comment; β-methylamino-l- alanine (BMAA), a toxin produced by blue-green algae (cyanobacteria) mimics & replaces serine causing mis-folded proteins leading...