Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels.

https://www.ncbi.nlm.nih.gov/pubmed/23359310 Comment; Small study of 31 patients, crossover design–everybody had intervention-free and intervention intervals studied, improved pain control, fatigue & sleep problems without any significant adverse effects....

Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients

https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract Comment; Technical Australian paper demonstrating that low-dose naltrexone (LDN) affects Natural Killer T Lymphocyte calcium channels in cell membrane–calcium is an intra-cellular signal...