Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels

by | CIRS

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936421/

Comment; We keep learning more and more about the benefits of Curcumin, anti-allergic, IgE interruption, PGD2, 5-lipooxygenase, Leukotriene C4, Cox02, Phospholipase C-gamma-1, phosphorylation of mitogen-activated protein kinases, so many areas of control and regulation of the immune system are involved with Curcumin, Nuclear factor KB.  It’s enough to make me crave Indian food!

Biomol Ther (Seoul). 2014 Jan; 22(1): 27–34.

doi:  [10.4062/biomolther.2013.092]

PMCID: PMC3936421

PMID: 24596618

Xian Li,1 Yue Lu,2 Ye Jin,1 Jong-Keun Son,1 Seung Ho Lee,1,* and Hyeun Wook Chang1,*

Abstract

Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its inhibitory mechanisms in immunoglobulin E (IgE)/Ag-induced mouse bone marrow-derived mast cells (BMMCs) and in a mouse model of IgE/Ag-mediated passive systemic anaphylaxis (PSA). Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2) and 5-lipoxygenase (5-LO) dependent leukotriene C4 (LTC4) generation dose-dependently in BMMCs. To probe the mechanism involved, we assessed the effects of curcumin on the phosphorylation of Syk and its downstream signal molecules. Curcumin inhibited intracellular Ca2+ influx via phospholipase Cγ1 (PLCγ1) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-κB (NF-κB) pathway. Furthermore, the oral administration of curcumin significantly attenuated IgE/Ag-induced PSA, as determined by serum LTC4, PGD2, and histamine levels. Taken together, this study shows that curcumin offers a basis for drug development for the treatment of allergic inflammatory diseases.

Dr. Raymond Oenbrink
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