Comment; Low-level laser stimulation across the mouse skull benefits its brain’s mitochondrial cytochrome-c oxidase & ion channels. This can benefit a variety of neurodegenerative illness
Madison Hennessy1 and Michael R Hamblin2,3,4Author informationCopyright and License informationDisclaimerThe publisher’s final edited version of this article is available at J OptSee other articles in PMC that cite the published article.Go to:
Abstract
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. The mechanism of action involves photon absorption in the mitochondria (cytochrome c oxidase), and ion channels in cells leading to activation of signaling pathways, up-regulation of transcription factors, and increased expression of protective genes. We have studied PBM for treating traumatic brain injury (TBI) in mice using a NIR laser spot delivered to the head. Mice had improved memory and learning, increased neuroprogenitor cells in the dentate gyrus and subventricular zone, increased BDNF and more synaptogenesis in the cortex. These highly beneficial effects on the brain suggest that the applications of tLLLT are much broader than at first conceived. Other groups have studied stroke (animal models and clinical trials), Alzheimer’s disease, Parkinson’s disease, depression, and cognitive enhancement in healthy subjects.
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