Comment; A proteome is a set of all expressed proteins in a cell, tissue, or organism, and a systematic analysis of proteins within a defined system for their identity, quantity, and function is called proteomics. Nanotechnology promises other ways to diagnose Babesia & other illnesses. Babesia is a tick borne illness that presents with irregular fevers, chills, headaches, general lethargy, pain, and malaise. It can be lethal in immunocompromised folks. Very hard to diagnose with current lab techniques, help on help on the way?
RubenMagniaAlessandraLuchiniaLanceLiottaaRobert E.MolestinabShow morehttps://doi.org/10.1016/j.ijpara.2018.08.004Get rights and content
Babesiosis has been recognized as an emerging infectious disease in the United States.•
Proteomic analysis of Babesia microti infection in whole blood is a challenge.•
Advances in nanotechnology and mass spectrometry can circumvent the analytical roadblocks.•
This is the first known report to present a proteome description of B. microti in vivo.
Abstract
Proteomics of Babesia microti has lagged behind other apicomplexans despite recent genome and transcriptome studies. Here, we used a combination of nanotechnology and mass spectrometry to provide a proteomic profile of B. microtiacute infection. We identified ∼500 parasite proteins in blood with functions such as transport, carbohydrate and energy metabolism, proteolysis, DNA and RNA metabolism, signaling, translation, lipid biosynthesis, and motility and invasion. We also identified surface antigens with roles in the immune response to the parasite. This first evaluation of the B. microti proteome in erythrocytes provides information for the study of intracellular survival and development of diagnostic tools using mass spectrometry.
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