Comments; Incredible antimicrobial activity against “bad bugs”; skin, oral, respiratory, & GI. Inherent defenses we’ve had since primordial times, New Info

J Neuroimmunol. 2008 Aug 30;200(1-2):11-6. doi: 10.1016/j.jneuroim.2008.05.014. Epub 2008

Jul 7.

El Karim IA1, Linden GJ, Orr DF, Lundy FT.



Many neuropeptides are similar in size, amino acid composition and charge to antimicrobial peptides. This study aimed to determine whether the neuropeptides substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), displayed antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. SP, NPY, VIP and CGRP displayed variable degrees of antimicrobial activity against all the pathogens tested with the exception of S. aureus.

These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses.

Dr. Raymond Oenbrink
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