Protection against neurodegeneration with low-dose methylene blue and near-infrared light

by Dr. Raymond Oenbrink | CIRS, ElectroMagnetic Field Sensitivity, Functional & Integrative Medicine, ISEAI, Neurodegeneration & Brain Health

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428125/ Comment; 0.5-4 mg/kg Methylene blue with red to near-IR 620–1150 nm wavelength light from laser or LED can penetrate to the human brain with up to 2% energy absorption. They work independently & synergistically...

Intra brainstem connectivity is impaired in chronic fatigue syndrome

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://www.sciencedirect.com/science/article/pii/S2213158219303924 Comment; Impaired connectivity in the brainstem should be expected as it’s metabolically active. ME/CFS impairs mitochondrial oxidative phosphorylation. The brainstem is involved in transmission...

Are Pollutants Causing Heart Disease and Type 2 Diabetes? The Link Between Persistent Organic Pollutants and Metabolic Syndrome

by Dr. Raymond Oenbrink | CIRS, ISEAI

Are Pollutants Causing Heart Disease and Type 2 Diabetes? The Link Between Persistent Organic Pollutants and Metabolic Syndrome Comment; Jill Carnahan MD, an excellent communicator explains the actions of Persistent Organic Pollutants (POPs) in this short but thorough...

Shining light on the head: Photobiomodulation for brain disorders

by Dr. Raymond Oenbrink | CIRS, ElectroMagnetic Field Sensitivity, Functional & Integrative Medicine, ISEAI

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/ Comment; Brief summary. LASER Mechanism of Action Cytochrome-c oxidase:Nitric Oxide (NO) uncoupling to release the inhibitory effects of NO.Brief increase in reactive oxygen species triggers mitochondrial signaling...

Photobiomodulation and the brain: a new paradigm

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448311/ Comment; Low-level laser stimulation across the mouse skull benefits its brain’s mitochondrial cytochrome-c oxidase & ion channels. This can benefit a variety of neurodegenerative illness Madison...

Marked efficacy of metronidazole for the intestinal pseudoobstruction associated with systemic sclerosis

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://www.ncbi.nlm.nih.gov/pubmed/21372514# Comment; I was aware of Erythromycin being used as a prokinetic GI agent, metronidazole is a new one to me, one to keep in mind as it can also help with overgrowth of C. diff and other potential anaerobic pathogens. Azuma...

Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

http://apjai-journal.org/wp-content/uploads/2018/07/AP-011117-0188.pdf Comment; Great study demonstrating the reduced glycolytic reserve in Natural Killer (NK) T-Lymphocyte activity in Chronic Inflammatory Response Syndrome (CIRS) patients. Glycolysis is respiration...

Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients

by Dr. Raymond Oenbrink | CIRS, ElectroMagnetic Field Sensitivity, ISEAI

https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0083-4 Comment; Impaired TRPM3 activity in Natural Killer (NK) T lymphocytes can potentially be reversed with Pregnenolone, parent to sex steroids & Nifedepine a calcium channel blocker used to treat...

Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study.

by Dr. Raymond Oenbrink | CIRS, ElectroMagnetic Field Sensitivity, ISEAI

https://www.ncbi.nlm.nih.gov/pubmed/19453963 Comment; Interesting that those with a high RBC sed rate had the best response. Sed rate measures inflammation–but generally not fibromyalgia-type inflammation–yet still predicted the best response to LDN....

Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels.

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://www.ncbi.nlm.nih.gov/pubmed/23359310 Comment; Small study of 31 patients, crossover design–everybody had intervention-free and intervention intervals studied, improved pain control, fatigue & sleep problems without any significant adverse effects....

Effects of naltrexone on pain sensitivity and mood in fibromyalgia: no evidence for endogenous opioid pathophysiology.

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://www.ncbi.nlm.nih.gov/pubmed/19365548 Comment; This study is using “standard” dosing of Naltrexone, not “low” dose Naltrexone (LDN), yet still provides evidence that the mechanism does not involve classic brain opioid receptors. Younger...

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain

by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, ISEAI

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/ Comment; LDN has been used for years, though incompletely understood regarding how it works. We know it affects Natural Killer T-Lymphocytes, doesn’t seem to work solely by effects on the CNS opioid...