Membrane Damaging Toxins from Coagulase-Negative Staphylococcus Are Associated with Self-Reported Temporomandibular Disorder (TMD) in Patients with Chronic Fatigue Syndrome

by | CIRS, Functional & Integrative Medicine

https://www.tandfonline.com/doi/abs/10.1300/J092v12n03_03?journalCode=icfs20

Comment; How many of these folks had MARCoNS breaking down α-Melanocyte Stimulating Hormone which amplifies pain when α-MSH levels are low?

Lee N. Metcalf Bioanalytical Research Group, Department of Biological Sciences, University of Newcastle, Callaghan, NSW 2308, Australia, Neil R. McGregor &Timothy K. Roberts

Abstract

Objective: To assess whether there is any association between membrane damaging toxin production by Staphylococcus spp. and self-reported TMD symptom expression in a group of patients selected to have CFS.

Methods: Thirty-three defined Chronic Fatigue Syndrome (CFS) patients and 33 age- and sex-matched controls were assessed to evaluate the relationship between carriage of membrane damaging toxin producing Staphylococcus, CFS and temporomandibular dysfunction (TMD) symptoms.

Results: The CFS patients had an increased prevalence of face pain (Odds Ratio = 21.0, 95% CL 4.2-106, P < .001) and temporomandibular joint (TMJ) clicking/locking (OR = 5.7, 95% CL 1.4- 23.5, P < .007), and the coagulase-negative Staphylococcus maximum % âtoxin haemolysis per patient. Both multivariate and univariate analyses revealed an association between the membrane damaging ätoxin producing CoNS (MDT-CoNS) species per subject and face pain prevalence and intensity within both the CFS patients and the control subjects. No association was found between CoNS toxin production and TMJ clicking/locking. Importantly, α- and âtoxin production by CoNS was associated with patient reporting of arthritis.

Coanclusions: These data confirm the original observations of the association between MDT-CoNS and facial muscle pain (Butt et al., 1998; McGregor et al., 2003). These data also suggest that MDT-CoNS associated facial muscle pain expression represents a distinct clinical entity, which has an increased prevalence in CFS patients.

 

 

Dr. Raymond Oenbrink
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