Comment; Poland is having problems with tick-borne neuropsychiatric illnesses as well. Is this a case of improved recognition of a long-ongoing problem or has virulence increased? It’s a tough call at present; more to be revealed.
Szymon Brodziński, Tadeusz Nasierowski
FREE POLISH FULLTEXT:Zaburzenia psychotyczne w przebiegu zakażenia Borrelia burgdorferi – część I: epidemiologia, patogeneza, diagnostyka i leczenie neuroboreliozy
FREE ENGLISH FULLTEXT:Psychosis in Borrelia burgdorferi infection – part I: epidemiology, pathogenesis, diagnosis and treatment of neuroborreliosi
sSummary Borreliosis is a multisystem, bacterial, zoonotic infectious disease with diversified spectrumof symptoms, which may also include psychotic disorders. Clinical picture of the disease is often unspecific, which makes the diagnosis relatively difficult. Uncharacteristic process of borreliosis is a result of complex molecular strategies used by spirochetes to infect, disseminate and survive in host organism. Part I of the article is focused on the current knowledge about pathogenesis of Lyme Borreliosis (LB), especially neuroborreliosis. Additionally, epidemic situation in Poland and in Europe was presented. Also, typical clinical manifestations of LB were described. In the article, the crucial pathogenic cell mechanisms were depicted. The processes of infection and dissemination of Borrelia in host were presented. The most important strategies of evading the response of host immune system were also discussed. These mechanisms are probable cause of the chronic and uncharacteristic clinical picture of the disease, as they significantly impair host immune response to bacteria. Also, there were presented molecular processes of neural cells impairment, which may lead to observed clinical symptoms of neuroborreliosis. Furthermore, diagnostic methods, treatment guidelines and some of diagnostic problems were discussed.
- COVID UPDATE: What is the truth? - 2022-11-08
- Pathologist Speaks Out About COVID Jab Effects - 2022-07-04
- A Massive Spike in Disability is Most Likely Due to a Wave of Vaccine Injuries - 2022-06-30
