Comment; VIP “cleans out the dust & cobwebs and puts on a fresh coat of paint”. It truly is a miracle drug that can actually cure pulmonary hypertension–which typically has a life expectancy of about 5 years (I was diagnosed in 2014, cured in 2019). It also helps with pain, inflammation, mitochondrial function. It’s naturally produced in the body, only available from compounding pharmacies and can only be used when pre-requisites are met or it won’t work properly.
Vasoactive Intestinal Peptide (VIP)
Before getting to VIP the following is suggested;
Patient is treated sequentially in 30-day steps by;
1) Removal from exposure
2) Treatment with cholestyramine for at least one month and ongoing
3) Eradication biofilm-forming coagulase negative staphylococci (MARCoNS)
4) Discontinuance of consumption of gluten if they had a positive antigliadin antibody titer (three months minimum required)
5) Correction of abnormalities androgens (DHEA)
6) Correction of abnormalities in regulation of salt and water with synthetic desmopressin or Oxytocin as shown by simultaneous ADH and osmolality
7) Normalizing MMP9 with Pioglitazone 45 mg daily
8) Normalizing VEGF with high dose omega-3 fish oils (4.2 grams daily)
9) Correction of C3a with high dose statins
10) Attempting to correct C4a with Erythropoietin but only if entry criteria met;
11) Attempting to correct TGF beta-1 with Losartan 25-100 mg daily, monitoring blood pressure carefully.
Prerequisites for use of VIP:
1. Normal Lipase
2. No MARCoNS
3. ERMI<2 or HERTSMI2<10 (this is an ideal situation this rule can be “bent” a bit if other factors are OK).
4. Normal VCS
MAINTENANCE;
(1) At the end of a month of VIP 1-2 nasal puffs 4 times daily (qid), repeat lab parameters
(2) Most people, after 6 months can tolerate a reduced dose of VIP from qid to twice (bid), sometimes to once (qd) daily
(3) This VIP intranasal protocol has essentially cured a large group of chronic fatigue patients.
(4) FDA has designated VIP for treatment of Pulmonary Hypertension (other uses are off-label)
(5) Remember, if using VIP then sustaining exposure to toxin/WDB etc., everything “goes back to square one”.
(a) The response will be truncated and shortened however after recovery from symptoms by a course of VIP.
(b) Patients will tolerate longer periods of exposure as well.
7. Lipase levels can increase with VIP therapy. Increased lipase levels can be associated with pancreatitis. Pancreatitis can have a mortality rate approaching 50%.
8. The patient is responsible for having MONTHLY LIPASE LEVELS drawn and sent to us!
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