Blogs Written by Dr. Oenbrink

Opioid and Cannabis Co-Use among Adults With Chronic Pain Relations to Substance Misuse, Mental Health, and Pain Experience

The article validates my experiences. Opioid use is necessary for some patient's to control their pain. Cannabis co-use is a pretty good marker for non-physiologic pain, other "issues" that trouble the patient, cannabis is NOT the best way to deal with these issues, the "marijuana maintenance" program is not recovery for those who are trying to get out of the abuse/addiction situation.
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Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain.

Good study on the harms from even a single dose, but also lower doses given repetitively over a period of time and how it alters gene expression of nerve cells involved in the sense of smell. These nerves take a very short path to the mid-brain which manages a lot of our day to day metabolic activities--very dangerous! Satratoxin G is one of the trichothecene toxins produced by black mold. This class has been used by the US Dept of Defense as a bioweapon.
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GLA RESPONSE TO PROPOSED IDSA/AAN/ACR 2019 DRAFT LYME DISEASE GUIDELINES

The Global Lyme Aliance really "knocks it out of the park" with a huge homerun. Very thoughtful, detailed analysis that can cause one to question the IDSA recommendations for treating Lyme Disease. I agree with the GLA that we need a more aggressive approach to Lyme. When in doubt, treat the patient, not the labs!
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Could Eating Fish Increase Your Risk of Heart Disease?

Dr. Jill does her usual stellar job of addressing a complex issue. Trimethylamine N-oxide (TMAO) seems to be an interesting concept with conflicting theories--perhaps just not yet ready for prime time. I like her final suggestion for a balanced, preferably organic diet. The final word has not been spoken on this subject.
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NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

Reduced cerebral NAD+/NADH ratio means impaired energy metabolism in the cell. Supplementation with Nicotinamide Riboside lessened the damage, the pTau pathology and reversed the DNA damage, neuroinflammation, hippocampal apoptosis (cell death where memory is formed), and hippocampal neural synaptic connections.
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Oligodendroglia are protected from antibody-mediated complement injury by normal immunoglobulins ‘‘IV Ig’’

Many mechanisms of action of IV Immunoglobulins including penetration within the cell membrane and even the nucleus of diseased cells, regulation of the immune system in the disease process, some diseases respond better than others--implying that all of these diseases have differences in their mechanism of action and thus different treatment approaches for each will likely be more effective.
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Immunological evidence and regulatory potential for cell-penetrating antibodies in intravenous immunoglobulin

Not only does IgG penetrate into cells, but in healthy cells, it gets into the cytoplasm, in diseased cells, to the nucleus; where the action is in terms of cellular control. This speaks to the therapeutic value of giving Intra-Venous Immunoglobulin (IgG) for therapeutic purposes, even though only ~2% of IgG gets into the cell, putting it in the control center of the abnormal cell can have profound effects.
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Maybe It’s Lyme What happens when illness becomes an identity?

It is a problem, yet an understandable one. Few physicians are truly Lyme-literate, the infection is hard to diagnose with contradictory criteria from major organizations, false-negative labs common etc. Additionally numerous treatment modalities generally mean there is no 100% effective "gold standard" treatment-failures of treatment occur, followed by difficulty in diagnosis once again...
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Cigarette smoke exposure redirects Staphylococcus aureus to a virulence profile associated with persistent infection

Yet another reason to stop smoking, cigarette smoke worsens the virulence profile of Staph aureus causing increased biofilm production (among other things). Biofilms shield bacteria from antibiotics. Smoke also induces formation of small colonies--altered growth patterns in the bacteria in response to the smoke.
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Blogs Written by Dr. Oenbrink

image002 Dr. Raymond Joseph Oenbrink

417 Biltmore Avenue, Doctors Park # 2A, Asheville NC 28801

Phone: (828) 785-1850 , Fax: (828) 785-1802

Email: appt@AppWell.net

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